Neurosurgeon Rowan Fielding has a problem - when she gets mad, she kills with her mind. Her search for answers sends her toward her secretive biological family. In New Orleans, Deirdre Mayfair is desperate to escape from her aunt's oppressive house.

Season two continues the journey of Rowan Mayfair after she has unwittingly given birth to the demon Lasher. She is determined to understand what he has become – human or monster? – and to use him to fulfill her purpose as a healer, but when tragedy strikes, she must put aside her own desires and fight to protect her family.